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Ryan, a depressed man who believes he is getting nowhere in his life and plans to kill himself. In the middle of his attempted suicide, he is asked to watch his neighbor';s dog, Wilfred, but Ryan can only see Wilfred as a real person instead of an animal that everyone else sees. As they begin to bond more and become friends, Wilfred teaches Ryan a life lesson about people, love, and living.
Gann can be irresistibly gross at times while Wood is good at being hapless. Together they sometimes make quite a comedy team. Almost as good as Turner & Hooch.
Wilfred is intensely vulgar, and only guys around the age of 28 whose ears, and sensibilities, are covered with scar tissue will find nothing offensive. Otherwise, it's very funny.