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The series depicts bizarre animated escapades of pseudo-heroic scientist Dr. Rusty Venture, his competent, high strung bodyguard, and his two over-enthusiastic but not-especially-bright twin sons.
Beginning as a relatively straightforward Johnny Quest parody, over the course of its first two seasons The Venture Bros. developed a mythology as deep and rewarding as that of the comic books and sci-fi series that it was spoofing.