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The documentary takes a real look at a variety of patients with mysterious diseases in their lives. These patients try to find a diagnosis and find a cure for these diseases completely. Doctors address these cases by combining the power of global crowdsourcing with established medical expertise. Doctors eventually discover that each case will have a distinctive vision and is completely different from the others.
The series wisely stays in the realm of patients without short life expectancies, so weeks or months of research are possible. It also means no overtly tragic endings, even if all aren't perfectly happy.
The Netflix series definitely appeals to the logical, scientific parts of the brain, but it also goes straight for the heartstrings. It is an uplifting show, though not in the ways you might think.
Where the series really shines is in expanding the vision beyond mystery and into explorations of how being sick, particularly without much hope for any effective treatment, affects people's lives.