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Massively obese, yet loving and kind-hearted, professor Sherman Klump is painfully shy and a bit clumsy, so his romantic prospects are rather bleak. Klump is on the verge of a breakthrough in DNA restructuring when he meets an admirer of his, named Carla, who is a new teacher. He then decides to test a formula on which he's been working on himself. Suddenly, Klump is transformed into the slim, trim, and handsome Buddy Love; however, the drug also boosts his testosterone level, turning the likable Sherman into the arrogant, skirt-chasing Buddy.
There's bold work here from Murphy on grand scale of thespian commitment, yet the feature's sense of humor is more dreary than playful, killing the potential of the premise with a constant display of bad taste.
[Murphy] is able to invest his Professor Klump with an endearing dignity, give his lounge lizard alter ego, Buddy Love, an alligator's bite and then go on from there to play Klump's grandma. Also his mother, father and brother.