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After a young man is bitten on the hand by a radioactive snake, his hand changes into a lethal snake head, which attacks everyone he comes into contact with. Also, his body becomes filled with snakes. Now, he must prevent himself from hurting others.
Director Prosperi and special effects wizard Screaming Mad George pull out all the stops during the second half, leading toward a snaky, hellish, rainswept climax boasting tension, creative innovation, and true showmanship.